The effect of nitrogen mustards upon the ultraviolet absorption spectrum of thymonucleate, uracil and purines.
نویسندگان
چکیده
In a previous paper (2) it was demonstrated mat nitrogen mustards caused a considerable decrease in the viscosity of sodium thymonucleate solutions. The present work was undertaken to determine whether this effect was due to an interaction of the nitrogen mustards with thymonucleate or some of its constituents. An interaction between nitrogen mustards and thymonucleate was demonstrated but could not be correlated with the effect on viscosity.
منابع مشابه
The effect of nitrogen mustards on the viscosity of thymonucleate.
The nitrogen mustards used in these experiments were the hydrochlorides of ethyl bis (/3 chloroethyl) amine, methyl bis (/3 chloroethyl) amine, and tris (fl chloroethyI) amine. Sodium nucleate was prepared from calf thymus by a modification of Hammarsten's procedure (5). After the preliminary extraction, filtration, and addition of CaC12, a precipitate was obtained by bringing the final ethanol...
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ورودعنوان ژورنال:
- Cancer research
دوره 6 11 شماره
صفحات -
تاریخ انتشار 1946